MRI (Magnetic Resonance Imaging) Contrast agents are used in MRI scans to enhance the effectiveness of the scan. They are injected approximately two-thirds of the way through the scan. All MRI Contrast agents are toxic. Their toxicity is reduced by rendering them as Chelates. They combine a metallic ion with a biological compound, creating a more "palatable" substance to introduce to the vascular system. All MRI Contrast doses are near to the lethal dose of the toxic metallic ion they contain.
Common Side Effects
There are a number of common side effects associated with MRI Contrast injections. These are normal side effects and are considered mild. They cause a significant amount of discomfort and pain to the patient and can last a period of a few hours to days. These side effects include allergic reaction, flushing or redness of the skin causing sensitivity to touch and/or a strong itching sensation, hives on the skin that can blister and ooze, blood clots throughout the body which can lead to numerous serious medical issues, some of which can be fatal, dizziness and disorientation, shortness of breath or an inability to "catch one's breath."
Less Common Side Effects
There are many other side effects that have been observed with the use of MRI Contrast. These are much less common than the previously mentioned ailments, however, they are notable in their behavior and how they affect the patient. These side effects include nausea and vomiting, headaches and migraines, rashes accompanied by bumps, hot and/or cold flashes for extended periods of time, and burning sensations under the skin or in the muscle or joint tissue.
Kidney Disease
MRI Contrast Agents, such as Omniscan and other gadodiamide based agents, have been linked to the development of NSF(Nephrogenic Systemic Fibrosis) in MRI patients with any history of kidney disease.
NSF
U.S. and European associations are researching further the link between gadodiamide and NSF. NSF is a rare systemic disease. It causes a thickening and hardening of the skin, often leading to immobility and tightness or deformity of the joints. These symptoms can develop rapidly and leave the affected patient wheel-chair bound for as little as a few weeks. At this time, there is no known, consistently effective, therapy or treatment for the bodily response to gadolinium.
Black Box Warning
In 2006, the FDA issued a health advisory warning concerning the dangers of gadolinium, and then in 2007 added a black box warning to the agents because of the risks associated with using gadolinium for patients with kidney conditions. For those with kidney conditions, it is recommended not to use gadolinium with MRIs because of the dangerous risks. If it is necessary to use gadolinium on a patient with kidney conditions, it is highly recommended to put the patient immediately on dialysis to flush out any remaining contrast in the systems.
Tags: kidney conditions, side effects, with kidney, with kidney conditions, associated with, Contrast agents, effects include
