Tamoxifen is a drug used to treat and prevent breast cancer in men and women. It works by blocking estrogen, a female sex hormone, in breast tissue. However, it also stimulates estrogen in the lining of the uterus, in bone and lipids. Tamoxifen is associated with side effects, some of which may be serious.
Common Side Effects in Women
Women taking tamoxifen often report symptoms similar to menopause. The most common symptom is hot flashes, but mood changes, vaginal dryness or discharge, headaches, nausea, vomiting, fatigue and skin rashes may also occur.
Common Side Effects in Men
In addition to headaches, nausea, vomiting and skin rashes, men may also experience decreased interest in sex and an inability to get or maintain erections.
Serious Side Effects
Tamoxifen has also been associated with more serious side effects, including cataracts, strokes, pulmonary embolism, deep vein thrombosis, and cancer of the uterus and uterine lining. In some patients, elevated levels of calcium may develop.
Contraindications
Tamoxifen should not be taken by women who have a history of blood clots or who are taking anticoagulant medications.
Tamoxifen and Antidepressant Therapy
Women on tamoxifen therapy often take antidepressant drugs to help alleviate side effects. One study presented at the 2009 American Society of Clinical Oncology Annual Meeting reported that certain antidepressant drugs may increase the likelihood of breast cancer recurrence. However, another study presented at the same meeting did not.
Tags: antidepressant drugs, associated with, breast cancer, Common Side, Common Side Effects
