Premarin cream is a prescription topical cream for vaginal use. Despite its effectiveness at relieving vaginal dryness and soreness related to menopause, the estrogen contained in Premarin poses a risk for adverse effects.
Types of Common Side Effects
Common side effects of Premarin cream include abdominal or back pain, weakness, headaches, diarrhea, nausea, joint pain, insomnia, coughing, sinusitis, breast pain and changes in vaginal discharge.
Significance
Approximately 66 percent of women who use Premarin cream experience at least one side effect, according to clinical trials published by the Food and Drug Administration.
Drug Interactions
When taken with antibiotics such as erythromycin or antifungals such as ketoconazole, Premarin has the potential to cause uterine bleeding or a return of menstrual periods.
Risks
Because some of the estrogen contained in Premarin cream is absorbed into the bloodstream, use of the medication poses a risk for blood clots and stroke, and increases your risk of developing uterine or breast cancers. Additional risks associated include dementia, gall bladder disease, temporary or permanent blindness and hypothyroidism.
Considerations
Premarin can cause harmful effects to a developing fetus and cannot be used during pregnancy. If you have a history of asthma, epilepsy, cancer, kidney disease, jaundice, diabetes, endometriosis, heart attack, stroke, hypertension, liver disease or dysfunction, lupus, thyroid disease, or migraines, it might not be safe for you to use Premarin cream.
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